Overview
Work in the Farrar Lab is focused on lymphocyte differentiation and function. We are pursuing this via three main areas of investigation. First, we have a long-standing interest in the development and function of regulatory T cells, which play a key role in preventing autoimmune disease, imprinting tolerance to commensal organisms, and reducing inflammation following infections. Second, we have been investigating the genetic circuits that regulate B cell development and exploring how mutations that affect these circuits drive B cell transformation in mice and humans. Third, and most recently, we have been tracking the CD4 T cell immune response to B cell leukemia and examining how combination chemotherapy and immunotherapy synergize to eliminate leukemia. We use cutting edge single-cell technologies, spatial transcriptomics/ proteomics and novel mouse models to explore these questions.
Research Areas
Recirculating T Regulatory Cells as a regulator of de novo T reg development
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Mechanisms of Tr1 cells in Acute Lymphoblastic Leukemia
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Interferon Stimulated Gene (ISG) expressing T Regulatory Cells in the context of infection
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Funding
Our research is generously supported by [Funding Agency 1], [Funding Agency 2], and [Funding Agency 3]. We are grateful for their support.