Publications

Full list also available on Google Scholar

H I G H L I G H T S

• 2007

  IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

  Burchill MA, Yang J, Vogtenhuber C, Blazar BR, Farrar MA

  J Immunol. 2007 Jan 1;178(1):280-90

  DOI → 10.4049/jimmunol.178.1.280
• 2008

  Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.

  Burchill MA, Yang J, Vang KB, Moon JJ, Chu HH, Lio CW, Vegoe AL, Hsieh CS, Jenkins MK, Farrar MA

  Immunity. 2008 Jan;28(1):112-21

  DOI → 10.1016/j.immuni.2007.11.022
• 2019

  Thymic regulatory T cells arise via two distinct developmental programs.

  Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN, Hekim C, Jeschke JC, Aggarwal P, Broeckel U, LaRue RS, Henzler CM, Alegre ML, Anderson MS, August A, Marson A, Zheng Y, Williams CB, Farrar MA

  Nat Immunol. 2019 Feb;20(2):195-205

  DOI → 10.1038/s41590-018-0289-6

2026

• Manuscript coming soon!

  Joo S, Owen DL, ..., Farrar MA

  Journal Name, Volume(Issue):Pages

  DOI →

2025

• Leukemia escapes immunity by imposing a type 1 regulatory program on neoantigen-specific CD4+ T cells.

  Venkatesh H, Granados Centeno E, Luo Q, Arroyo M, Heltemes-Harris L, Knutson TP, Qiu Y, Haaning A, Webber BR, Bachanova V, Farrar MA, Tracy SI

  Blood, 146(23):2779-2793

  DOI → 10.1182/blood.2024028194

• PDL1 Checkpoint blockade synergizes with Nilotinib but not Dasatinib to prevent leukemia relapse.

  VMorgan EC, Venkatesh H, Centeno EG, Heltemes-Harris LM, Hubbard G, Maiers TL, Dileepan T, Tracy SI, Farrar MA

  BbioRxiv [Preprint]

  DOI → 10.1101/2025.07.02.662848

2023

• Cytotoxic CD4 T cells in the mucosa and in cancer.

  Venkatesh H, Tracy SI, Farrar MA.

  Front Immunol, 2023 Aug 16;14:1233261

  DOI → 10.3389/fimmu.2023.1233261

2022

• Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation.

  Lee RD, Knutson TP, Munro SA, Miller JT, Heltemes-Harris LM, Mullighan CG, Jepsen K, Farrar MA

  Nat Immunol. 2022 Dec;23(12):1763-1776

  DOI → 10.1038/s41590-022-01343-7

• Tracking Regulatory T Cell Development in the Thymus Using Single-Cell RNA Sequencing/TCR Sequencing

  Owen DL, La Rue RS, Munro SA, Farrar MA

  J Immunol. 2022 Oct 1;209(7):1300-1313

  DOI → 10.4049/jimmunol.2200089

• Combining nilotinib and PD-L1 blockade reverses CD4+ T-cell dysfunction and prevents relapse in acute B-cell leukemia

  Tracy SI, Venkatesh H, Hekim C, Heltemes-Harris LM, Knutson TP, Bachanova V, Farrar MA

  Blood. 2022 Jul 28;140(4):335-348

  DOI → 10.1182/blood.2021015341

2021

• Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation.

  Lee RD, Munro SA, Knutson TP, LaRue RS, Heltemes-Harris LM, Farrar MA

  Nat Commun. 2021 Nov 25;12(1):6843

  DOI → 10.1038/s41467-021-27232-5

• Phenotypic and Functional Diversity in Regulatory T Cells.

  Sjaastad LE, Owen DL, Tracy SI, Farrar MA

  Front Cell Dev Biol. 2021 Sep 23;9:715901

  DOI → 10.3389/fcell.2021.715901

• Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia.

  Heltemes-Harris LM, Hubbard GK, LaRue RS, Munro SA, Yang R, Henzler CM, Starr TK, Sarver AL, Kornblau SM, Farrar MA

  Oncogene. 2021 Oct;40(43):6166-6179

  DOI → 10.1038/s41388-021-02012-z